Scripties UMCG - Rijksuniversiteit Groningen
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Hypothyreoïdie / Hyperthyreoïdie en “kwaliteit van leven” in het LifeLines Onderzoek

(2010) Stienstra, R.

Hypothyroidism is a thyroid disorder with many symptoms including fatigue, depression and weight gain. Thyroid dysfunction may also affect the quality of life. In this study, with 10,018 participants from the LifeLines Study (aged 18 - 90 years) we investigated the quality of life and health status. The goal of this study was to investigate whether there is a difference in quality of life and health status between participants with hypothyroidism and participants with a normal thyroid function. 9657 participants were not known to have a thyroid disorder. They also did not use medication for thyroid disorders. The study population of 9657 participants was classified into 4 groups. A controlgroup of participants with euthyroidism (TSH between 0,4 and 3,99 mU/L) and three groups of participants with abnormal TSH values. The RAND 36 score of participants with hypothyroidism (n=79) or hyperthyroidism (n=77) was compared with the score of those with normal thyroid function (n=8493). In this study, we did not find a significant difference in quality of life between participants with a high TSH value and participants with normal thyroid function.
The prevalence of diabetes mellitus, hypertension, previous myocardial infarction and elevated cholesterol levels is determined for all four TSH groups. More participants with hypothyroidism (TSH group 3) have a higher cholesterol level compared with LifeLines participants with normal TSH levels (TSH group 1). Diabetes mellitus and hypertension is more common in participants who have low TSH levels - hyperthyroidism (TSH group 0) – compared with participants with a normal thyroid function.

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