Scripties UMCG - Rijksuniversiteit Groningen
 
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The relation between CT-based measurements of skeletal muscle mass and post-operative complications after HIPEC treatment for peritonitis carcinomatosis

(2017) Luit, L.R. van

Introduction - Peritonitis carcinomatosis (PC) is a disease, characterized by metastasized
tumors in the abdominal cavity, causing an inflammation reaction of the peritoneum. A
relatively new treatment for this disease is Hyperthermic Intraperitoneal Chemotherapy
(HIPEC), preceded by cytoreductive surgery (CRS). Research has shown a relation between
depletion of skeletal muscle mass (sarcopenia) and the incidence of postoperative
complications in patients treated for colon carcinoma. A similar relation, specific for patients
after HIPEC treatment, is being investigated in this research.
Methods - In this research, data of 104 patients is analyzed. The degree of skeletal muscle
mass depletion was analyzed by CT measurements of the cross-sectional area of all skeletal
muscle mass (SMI) or both psoas muscles (TPI) at the L3 vertebral body level.
Results - 31 (29.9%) patients were classified as sarcopenic using the SMI, and 2 (1.9%)
patients were classified as sarcopenic using the TPI. Hospitalization period (OR: 1.08; 95%
CI: 1.02-1.15; p = 0.01) and number of organs removed (OR: 1.76; 95% CI: 1.26-2.47; p <
0.01) were independent statistical significant risk factors associated with the incidence of
postoperative complications
Conclusion - In this research, no relationship between sarcopenia and the development of
postoperative complications could be demonstrated.






 
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