Scripties UMCG - Rijksuniversiteit Groningen
English | Nederlands

The effect of smoking on cardiac structure and function

(2018) Alsabaan, N. (Najod)

Background: cardiovascular disease (CVD) is the main cause of mortality worldwide.
Smoking is an important risk factor for CVD. The mechanism linking smoking with CVD is
not yet clear. Most of the evidence for the effects of smoking in relation to cardiac structure
and function is based on echocardiography. Magnetic resonance imaging (MRI) has high
spatial and temporal resolution and is more accurate in assessing cardiac structure and
function. Therefore, the aim of this study was to assess the effects of smoking on cardiac
structure and function as assessed by MRI. Methods: this case-control study included
participants from the UK biobank study free from major CVD. Smokers and non-smokers
were matched on age, sex and body surface area. MRI imaging analysis was performed using
CircleCvi42 post-processing software. Independent t-test, Mann-Whitney U test and chisquared
test were performed to compare the data between smokers and non-smokers.
Bonferroni correction was conducted to correct for type one errors. Results: we matched 103
smokers with non-smokers. The mean age was 58 (7.5) years. Smokers consumed more units
of alcohol (P= 0.024) and had lower incomes (P= 0.015) as compared to non-smokers.
Global longitudinal strain (GLS), global radial strain (GRS) and ejection fraction (EF) were
lower in smokers as compared to non-smokers (P-value= 0.002, 0.01and 0.012, respectively).
After Bonferroni correction, GLS remained the only significant variable with lower values in
smokers as compared to non-smokers. Conclusion: Our results add to the knowledge on the
effects of the established cardiac risk factor smoking on cardiac structure and function by
showing a significantly lower GLS in smokers as compared to non-smokers. These results
seem to indicate that smoking causes subclinical alterations in myocardial function, which are
possibly due to changes in myocardial structure.

To top