Scripties UMCG - Rijksuniversiteit Groningen
 
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De gemodificeerde tweemaal 32-slice CT scan is net zo betrouwbaar als de 64-slice CT scan in het uitsluiten van coronaire Een retrospectief multi-center onderzoek in Noord Oost Nederland

(2019) Hobers, M. (Mitchell)

The purpose of this study is to assess the diagnostic accuracy of the Siemens Biograph mCT 64
scan TrueV UHD CT scan, which in reality is a double 32-slice CT scan, in patients living in the
North East of the Netherlands suspected of coronary artery disease (CAD). The findings of the
computed tomography coronary angiography (CTA) are compared to the findings of the golden
standard, in this case invasive coronary angiography (ICA) with eventual an instantaneous wavefree
ratio (iFR) or an fractional flow reserve (FFR) measurement. 662 patients underwent CTA, in
which 552 patients didn’t underwent ICA. 53 patients were excluded for several reasons.
77 patients underwent CTA and ICA. The diagnostic accuracy of the CTA to prove or rule out significant
CAD (>50% stenosis) is investigated per patient, per segment and per whole vessel.
For patient-based analysis, CTA had a sensitivity of 64,5%, a specificity of 60,9%, a positive predictive
value of 52,6% and an negative predictive value of 71,8%. For the segments, CTA had a
sensitivity of 37,2, a specificity of 95,8%, a positive predictive value of 45,5% and an negative
predictive value of 94,5%. For the whole vessel, CTA had a sensitivity of 50,9%, a specificity of
88,9%, a positive predictive value of 44,5% and an negative predictive value of 90,3%.
Our results demonstrates that the Siemens Biograph mCT 64 TrueV UHD CT scan is just as reliable
to rule out significant CAD compared to a 64-slice CTA. And therefore, it could be used as a safe
alternative instead of the ICA in patients with low to intermediate risk of CAD. Because of the low
numbers of true positive results on the CTA there can been none pronouncement done regarding the
ability to prove CAD.






 
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