Scripties UMCG - Rijksuniversiteit Groningen
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Verminderde handknijpkracht en loopsnelheid bij ouderen is geassocieerd met het optreden van negatieve klinische uitkomsten

(2019) Zwartjens, J. (Judith)

Introduction: Frailty is a term used to describe the overall condition of the elderly. The
determination of degree of frailty can be time-consuming and is generally difficult. The
physical frailty phenotype (PFP) is the most commonly used instrument for assessing frailty.
It consists of 5 components; unintentional weight loss, reduced grip strength, poor endurance,
reduced gait speed and low physical activity level. It is not known whether reduced grip
strength and gait speed alone are related to adverse outcomes (hospitalization, falls, death).
Different cut-off values for grip strength and gait speed are used in literature, such as the PFP
and that of Dodds and Studenski, which we have investigated.
Methods: This is a retrospective cohort study in patients of the geriatric outpatient clinic of
Deventer Hospital. Grip strength and gait speed were measured as standard procedure. Cut-off
values of the PFP and Dodds and Studenski were grip strength ≤ 18 kg and <16 kg for
women, ≤ 30 kg and <27 kg for men and gait speed ≤ 0,76 m/s and <0,60 m/s, respectively.
Follow-up lasted until 6 months after measurement, to record whether adverse outcomes had
Results: Grip strength and/or gait speed was measured in 492 patients. After correction for
confounders, only reduced grip strength and the combination of reduced grip strength and gait
speed according to the PFP was associated with adverse outcomes (OR 3,807 (95% BI: 1,757-
8,248) and 2,073 (95% BI: 1,092-3,933)).
Conclusion: Reduced grip strength and the combination of reduced grip strength and gait
speed based on the PFP are independently associated with adverse outcomes. The
combination seems best to assess the risk of adverse outcomes. For risk assessment of adverse
outcomes, the cut-off values of the PFP are most accurate.

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